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Single Cell Sequencing School 2020

Oleg Shpynov presented the talk Understanding single cell ATAC-seq data on the mini-conference during the 2nd Single-Cell Sequencing Workshop organized by Tomsk National Research Center, The Russian Academy of Science.

The talk was dedicated to the recent paper "Comprehensive profiling of an aging immune system reveals clonal GZMK+ CD8 T cells as conserved hallmark of inflammaging" where the authors described novel immune cell populated associated with inflammaging and identified potential targets to develop therapy for inflammation related disease in aging.

Covered topics:
  • Single Cell ATAC-seq protocol
  • Assessment of existing computational methods
  • Methods used in the paper for analysing multiple scATAC-seq experiments for different conditions